Xray Irradiation Promotes Nerve Growth Factor-induced Neurite Extension in PC12 Cells
نویسندگان
چکیده
منابع مشابه
Reconstituted basement membrane enhances neurite outgrowth in PC12 cells induced by nerve growth factor.
Rat pheochromocytoma cells (PC12) respond to nerve growth factor (NGF) by elaborating neurites. We have studied the effect of extracellular matrix proteins on responsiveness of PC12 cells to NGF. NGF elicited neurite outgrowth in cells plated on collagen, fibronectin, or laminin within 48-72 h. In contrast, cells entrapped in reconstituted basement membrane prepared from the Engelbreth-Holm-Swa...
متن کاملNerve Growth Factor-Induced Neurite Sprouting in PC12 Cells Involves -1 Receptors: Implications for Antidepressants
One theory concerning the action of antidepressants relates to the drugs’ ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to -1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hypothes...
متن کاملNerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides.
The PC12 rat pheochromocytoma cell line is an established model for nerve growth factor (NGF)-induced neurite formation. It has been shown that when gangliosides are added to the culture medium of PC12 cells, NGF-induced neurite formation of PC12 cells is enhanced. To determine the role of endogenous cellular gangliosides themselves in NGF-elicited neurite formation, we depleted cellular gangli...
متن کاملNerve growth factor-induced neurite sprouting in PC12 cells involves sigma-1 receptors: implications for antidepressants.
One theory concerning the action of antidepressants relates to the drugs' ability to induce an adaptive plasticity in neurons such as neurite sprouting. Certain antidepressants are known to bind to sigma-1 receptors (Sig-1R) with high affinity. Sig-1R are dynamic endoplasmic reticulum proteins that are highly concentrated at the tip of growth cones in cultured cells. We therefore tested the hyp...
متن کاملPC12 cells express juvenile microtubule-associated proteins during nerve growth factor-induced neurite outgrowth
Microtubule-associated proteins (MAPs) are believed to play an important role in regulating the growth of neuronal processes. The nerve growth factor-induced differentiation of PC12 pheochromocytoma cells is a widely used tissue culture model for studying this mechanism. We have found that contrary to previous suggestions, the major MAPs of adult brain, MAP1 and MAP2, are minor components of PC...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RADIOISOTOPES
سال: 2016
ISSN: 0033-8303,1884-4111
DOI: 10.3769/radioisotopes.65.137